C29-carboxylic acid intermediates of cholesterol biosynthesis in rat liver
نویسندگان
چکیده
منابع مشابه
Terpenoid intermediates in the biosynthesis of cholesterol.
Previous reports from this laboratory (1, 2) have described a particlefree extract of rat liver which is capable of incorporating C14-labeled acetate and P-hydroxy+methylglutaric acid (HMG)’ into cholesterol. With this enzyme system, it has been possible to demonstrate that acetate and HMG can be incorporated into squalene, and that biosynthetic Cr4-labeled squalene is incorporated into cholest...
متن کاملIntermediates of salicylic acid biosynthesis in tobacco
Salicylic acid (SA) is an important component of systemic-acquired resistance in plants. It is synthesized from benzoic acid (BA) as part of the phenylpropanoid pathway. Benzaldehyde (BD), a potential intermediate of this pathway, was found in healthy and tobacco mosaic virus (TMV)-inoculated tobacco (Nicotiana tabacum L. cv Xanthi-nc) leaf tissue at 100 ng/g fresh weight concentrations as meas...
متن کاملDetermination of Key Intermediates in Cholesterol and Bile Acid Biosynthesis by Stable Isotope Dilution Mass Spectrometry
For more than a decade, we have developed stable isotope dilution mass spectrometry methods to quantify key intermediates in cholesterol and bile acid biosynthesis, mevalonate and oxysterols, respectively. The methods are more sensitive and reproducible than conventional radioisotope (RI), gas-chromatography (GC) or high-performance liquid chromatography (HPLC) methods, so that they are applica...
متن کاملRegulation of rat liver glycogen synthetase. Carboxylic acid activation of liver glycogen synthetase.
Rat liver glycogen synthetase is strongly stimulated by cellular carboxylic acids which are intermediates of glycolysis and the tricarboxylic acid cycle. Activation of glycogen synthetase by the carboxylic acids may coordinate hepatic glycogen deposition with the functional status of the tricarboxylic acid cycle. At physiological concentrations of the carboxylic acids, the I form is preferentia...
متن کاملThe biosynthesis of guanidinosuccinic acid by perfused rat liver.
The metabolic pathway for the synthesis of guanidinosuccinic acid was studied in the rat. Labeled guanidinosuccinic acid was isolated from the urine of animals given L-[guanidino-14C]arginine intraperitoneally but did not appear in the urine after administration of D,L-[guanidino-14C]canavanine. Radioactive arginine and nonradioactive aspartic acid and arginine were infused in the isolated, per...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Biochemical Journal
سال: 1971
ISSN: 0306-3283
DOI: 10.1042/bj1220024pc